In order to target this population, Lin J et al. designed innovative splicing-modulating steric hindrance antisense oligonucleotides (shAONs) targeting the glycine decarboxylase (GLDC) gene, whose protein is a metabolic enzyme overexpressed in TICs of NSCLC, and necessary for their maintenance [31]. This evidence concerns the gene GLDC and non-small cell lung carcinoma.