FHIT and neoplasm: This leads to the re-expression of methylation-silenced tumor-suppressor genes, such as fragile histidine triad protein (FHIT), CDKN2A, cadherin-13 (CDH13), cadherin-1 (CDH1) and Ras Association Domain Family Member (RASSF1A) both in vitro and in vivo [65].