SESN1 and lung carcinoma: In addition, Cortez and co-workers have shown that miR-200c promotes radiosensitivity of lung cancer cells by controlling the oxidative stress response through the direct regulation of Peroxiredoxin 2 (PRDX2), GA-binding protein (GAPB/Nrf2) and Sestrin 1 (SESN1), and by preventing the repair of radiation-induced double-strand breaks [82].