THBS1 and cancer: The miR-17/92 cluster is typically amplified in lung cancer and targets different genes, such as Hypoxia-inducible factor 1-alpha (HIF-1α), PTEN, BCL2-like 11 (BCL2L11), cyclin dependent kinase inhibitor 2A (CDKN2A) and Thrombospondin-1 (TSP-1), which are involved in cancer cell death and proliferation [59].