Strikingly, the phototherapy resulted in a decrease in mRNA expression of some pro-inflammatory markers (il1b, il6, tnfa, and nfkbiab) and oxidative stress modulators (romo1, coa1, and slc2a1a) in the tissues affected by the cytokine storm syndrome (CSS) associated with COVID-19. This evidence concerns the gene ROMO1 and COVID-19.