TNF and COVID-19: The results of the chord diagram in human tissue with COVID-19 showed the transcriptional signature of pro-inflammatory markers, such as nfkbiab, tnfa, il1b, and il6, including the genes romo1 (reactive oxygen species), coa1 (cytochrome c oxidase 1), and slc2a1a (glucose transporter 2) involved in the processes of reactive oxygen species production, mitochondrial respiratory chain, and cell membrane glucose transport (Figure 1B).