BCR and lymphoma: The activation of ‘chronic’ or ‘tonic’ BCR signaling in lymphoma B cells can be influenced by a specific immunoglobulin structure, the expression and mutations of adaptor molecules (like GAB1, BLNK, GRB2, and CARD11), the activity of kinases (like LYN, SYK, and PI3K) or phosphatases (like SHIP-1, SHP-1, and PTEN) and levels of oncogenic miRs, predominantly miR-155-5p [379].