Although the dietary intake of BPA is below the European Food Safety Authority’s temporary tolerable daily intake, exposure to BPA through milk consumption may have a critical impact on lymphomagenesis as BPA augments β1-catenin/ERβ/IGF-1/IGF1R-signaling involved in the pathogenesis of DLBCL (Figure 1). Here, ESR2 is linked to diffuse large B-cell lymphoma.