Gene mutations in DLBCL disturb various signaling pathways including histone modification, cell growth, proliferation, metabolism, differentiation, apoptosis, survival, homing/migration, response to DNA damage, B-cell receptor (BCR), signaling, Toll-like receptor (TLR) signaling, angiogenesis, and immunoregulation [10,13,14,15,16,17,18,19]. Here, BCR is linked to diffuse large B-cell lymphoma.