Of note, CLL-derived microvesicles (MV) can activate the AKT/mTORC1/p70S6K/hypoxia-inducible factor-1α axis in CLL-bone marrow stromal cells (BMSCs) with the production of vascular endothelial growth factor, a survival factor for CLL B-cells. This evidence concerns the gene VEGFA and B-cell chronic lymphocytic leukemia.