The inhibition of the TRPC5 channel with a small molecule (AC1903) reduced intracellular concentrations of G418 and consequently reduced the induction of PTC-readthrough in a cancer cell line (harboring a homozygous p53 nonsense mutation) and in junctional epidermolysis bullosa (JEB) patient-derived keratinocytes (harboring a homozygous mutation in COL17A1) [119]. This evidence concerns the gene TP53 and cancer.