ILC1s contributes to protective immune response directed against intracellular bacteria or viruses, as well as tumors through interferon-γ (IFN) [4]; ILC2s contribute to response to infections with extracellular parasites or microbes after being stimulated by allergens through interleukin (IL)-5, IL-9, and IL-13 [5]; ILC3s act against extracellular microorganisms (i.e., bacteria and fungi) through IL-22 and IL-17 [3,6]; and LTi cells play a crucial role in lymphoid tissue development during fetal life, and they may also help repair tissue in secondary lymphoid organs in adults. Here, IL22 is linked to infection.