According to the results of this study, EEFR effectively prevented epidermal hyperplasia and hyperkeratosis in DNFB-treated mice by inhibiting the production of TNF-α, IFN-γ, IL-6, and MCP-1, and thus, ameliorated scaling, erythema, excoriation, and skin thickening. The gene discussed is IFNG; the disease is Hyperkeratosis.