One mechanism of action of the correlation between vitamin B and cancer is related to a p53/p21-dependent change in the partitioning of glutamate conversion of 2-oxoglutarate through glutamate oxaloacetate transaminase (GOT2) or the glutamate dehydrogenase (GDH)-linked NAD(P)-dependent metabolism of 2-oxoglutarate in the affiliated thiamine pathway [24]. Here, TP53 is linked to cancer.