As for 4E-BP1, a mTOR independent regulation of this factor occurs in glioma cells [30], myoblasts [31], and acute myeloid leukemia [32], suggesting that 4E-BP1 activation could be regulated directly or indirectly by PI3K but not via Akt-mTORC1 [54]. The gene discussed is AKT1; the disease is central nervous system cancer.