Using a combination of proteomics and imaging techniques, a study in HEK293T cells reported the function of LRRK2 in mediating endosome-TGN transport by scaffolding the GARP–SNARE interaction (VAMP4; STX6), suggesting a connection between GARP and LRRK2 in Parkinson’s disease. The gene discussed is LRRK2; the disease is Parkinson disease.