RHOA and pancreatic ductal adenocarcinoma: On the other hand, in pancreatic ductal adenocarcinoma (PDAC), EIF5A1 mediates PDAC cell migration and invasion by modulating RhoA/ROCK protein expression levels while pharmacological inhibition or genetic knockdown of EIF5A1 reduces PDAC cell migration, invasion, and metastasis in vitro and in vivo [21].