Nevertheless, ROS has been reported as a central element in the early induction of mitochondrial membrane potential alterations and thus an important trigger of Cytochrome C release, in this sense, human neuroblastoma cells treated with EpoB observed a reduction of mitochondria-confined cytochrome C by 66% after 6 h of treatment, with a maximum reduction in 83% at 24 h [57]. Here, CYCS is linked to neuroblastoma.