For instance, ixabepilone, KOS-862 (Epothilone D), and ZK-EPO (sagopilone) show high incidences of myelosuppression, alopecia, peripheral neuropathy, and hypersensitivity reactions [82,83], whereas patupilone has a milder toxicity profile characterized by diarrhea and fatigue [82,83]. The gene discussed is EPO; the disease is alopecia.