TP53 and colonic neoplasm: The activation of p53 is an early event of the intrinsic apoptotic pathway that leads to the activation of different proteins and apoptogenic factors, which would explain the report by Lee, et al. [53] who observed in the human colon cancer cell line SW620 (p53+) that EpoB can trigger the expression of the active form of caspase-3 together with the proapoptotic proteins Bax, p53 via an NF-κB-dependent pathway and at the same time, reduce the expression of the antiapoptotic protein Bcl2 [53].