Various pharmacological agents, such as paenolol, sodium butyrate, vitamin D, astaxanthin, isoeucommin A, dapagliflozin, and sulforaphane, have displayed benefits in ameliorating diabetic nephropathy in animal models by directly or indirectly inducing NRF2 expression [109,110,111,112,113,114,115]. This evidence concerns the gene NFE2L2 and diabetic kidney disease.