NFE2L2 and hypertensive disorder: In vivo study with Dahl salt-resistant rats showed that indoxyl sulfide, as well as hypertension, can decrease NRF2 expression and its targeted genes, such as HO-1 and NQO1, and increase renal expression of 8-hydroxydeoxyguanosine (8-OHdG), a marker of reactive oxygen species (ROS).