NFE2L2 and early-onset autosomal dominant Alzheimer disease: For instance, NRF2 and HO-1 are both important biomarkers involved in cellular defense against oxidative stress and inflammation, and has been adopted in several diseases, including pediatric respiratory diseases [196], cardiovascular diseases [197], movement disorders [198], malignancy [199,200], Alzheimer’s diseases, and Parkinson’s disease [201].