Additionally, CDDO-Me increased NRF2 to compete with NF-κB for binding to the cyclic adenosine monophosphate response element binding protein (CREBP), which may contribute to the selective increase in NRF2 downstream targets, including NADPH Oxidase Quinone 1, HO-1, Catalase, and GCLC Subunit, and the alleviation of myocardial inflammation in chronic HF rats. This evidence concerns the gene NFE2L2 and hydrops fetalis.