Results from a biochemical analysis for 180 new-onset type 2 diabetes mellitus showed that gene expression of oxidative stress markers, such as transient receptor potential cation channel 6 (TRPC6), p22phox, suppressor of cytokine signaling 3 (SOCS3), and malondialdehyde (MDA) level were all increased significantly, along with T helper type 1(Th1)/T helper type 2 (Th2) ratio. Here, SOCS3 is linked to diabetes mellitus.