Along with FLT3 and DNA methyltransferase 3 alpha (DNMT3A; https://www.ncbi.nlm.nih.gov/gene/1788; accessed on 14 January 2023), nucleophosmin 1 (NPM1) is one of the three most frequent driver mutations in acute myeloid leukemia. This evidence concerns the gene DNMT3A and acute myeloid leukemia.