These problems include: (1) a lack of information because there were so few articles; (2) a lack of NQO1 levels during CYP2E1 activity in acute myeloid leukemia; (3) a lack of information about how gene polymorphisms affect the encoded protein; and (4) a lack of thought about how genes and the environment interact. Here, CYP2E1 is linked to acute myeloid leukemia.