PRKN and Parkinson disease: About 10% of PD cases are inherited and linked to genetic mutations in the SNCA (α-synuclein), PARK2 (Parkin), PINK1 (PTEN-induced kinase 1), PARK7 (DJ-1 deglycase protein), LRRK2 (repeated rich kinase leucine), and ATP13A2 (type ATPase 13A) genes.