DNMT3A and colorectal cancer: Huang et al. reported that EVO increases the expression of miR-152, miR-429, and miR-29a, which in turn downregulates DNA methyltransferase 1 (DNMT1), DNMT3A, and DNMT3B in colorectal cancer cells, resulting in reversing the epigenetic silencing of tumor suppressor genes and inhibiting cancer cell growth [51].