Cea et al. showed that suppression of nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme engaged in nicotinamide adenine nucleotide production, evoked related cytotoxic effects against MM cells resistant to routine anti-MM drugs in vitro and in vivo, and inhibits the preventive properties of IGF-1, interleukin-6, and BM stromal cells. Here, NAMPT is linked to Miyoshi myopathy.