In the present study, most of the hypercreatinemic patients with COVID-19 were found to have hyper-inflammatory status and coagulopathies, as these patients were having elevated levels of LDH, ferritin, D-Dimer, procalcitonin, Hs-CRP, and IL-1 and IL-6 compared to hypercreatinemic patients with COVID-19. This evidence concerns the gene MAP3K14 and blood coagulation disease.