The tissue necrosis of renal tissue causes the release of cellular biomarkers from renal tissue which includes ALP, LDH, TNF-α, and CPK which further increases/fuels the cytokine storm response and ultimately a vicious circle is initiated, which results in the progression of renal failure in patients with preexisting renal failure [30,31]. The gene discussed is PIK3C2A; the disease is Renal insufficiency.