Taken together, the above data suggested that THY1 can maintain the adherens junctions in NPC cells by the presence of PTPN22 to counteract SRC activation, which can be induced by PDGF-Rβ, and this is how NPC tumor invasion and metastasis can be inhibited by THY1. The gene discussed is PTPN22; the disease is nasopharyngeal carcinoma.