In NPC, elevated levels of SRC in serum and activated form of SRC in primary tissues were found to be associated with poor prognosis; the gain-of-function and loss-of-function analyses have demonstrated that SRC could induce EMT and enhance the metastasis potential in the EBV-negative CNE2 and SUNE1 cell lines used as the study models [17]. The gene discussed is SRC; the disease is nasopharyngeal carcinoma.