Taken together, this paper sought to investigate the underlying mechanisms of THY1-mediated anti-metastatic effects in NPC, and our data showed that THY1 could inhibit the SRC activity via interaction with PDGF-Rβ and PTPN22 in NPC cells, so as to protect the adherens junctions and suppress NPC metastasis. Here, SRC is linked to nasopharyngeal carcinoma.