SCD and glioblastoma: Inhibition of SCD also results in a decrease in MUFA and an accumulation of SFA in glioblastoma cells [73], leading to ER stress and apoptosis of glioblastoma cancer cells through activation of inositol-requiring enzyme 1 (IRE1) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK).