B lymphocytes can produce immunostimulatory cytokines (e.g., IL-6, IL-4, IL12p40, IL7, INF-γ, TNF, CCL3, IL-2, and colony-stimulating factor 2 CFS2 or GM-CSF) [60] and anti-inflammatory cytokines (IL-10, TGF-β, IL-35) [61] even within the tumor tissue [62]. Here, CSF2 is linked to neoplasm.