CXCL8 and cancer: Indeed, B lymphocytes can exert their protumorigenic function in different ways: boosting the development of cancer cells by activating Fcγ receptors (FcγR) on myeloid cells, sustaining the generation of new blood vessels in tumors, producing lymphotoxin which activates cancer resisting castration, or modulating the signals of the IL-8/androgen receptor which increase tumor metastasis.