CD8A and hepatocellular carcinoma: Experiments performed in Mdr2−/− mice under liver fibrosis condition showed that the depletion of CD20+ B cells with CD4+/CD8+ T induced inhibitory effects on liver cancer progression [139], while clinical studies in human patients revealed that B cells were notably decreased in HCC, and the density of tumor-infiltrating CD20+ B cells was positively correlated with superior survival [19,83].