For that, here, serum levels of interleukins (ILs) such as IL-4, IL-6, IL-10, and IL-17A, IFNγ (interferon-γ), GM-CSF (granulocyte and macrophage colony-stimulating factor), TGFβ (transforming growth factor β), and DCD (dermicidin) were assayed, and the RKIP, PIRIN, BCL2, BCL3, MITF, and ANXA5 proteins were assessed by immunohistochemistry (IHC) in melanoma biopsies from a group of melanoma patients. This evidence concerns the gene ANXA5 and melanoma.