Active FAK has been reported to be stabilized or upregulated in vitro by the receptor tyrosine kinase (RTK) EphA2, tissue transglutaminase (TG2), pancreatic adenocarcinoma upregulated factor (PAUF), and tetraspanin 8 (Tspan8), while being downregulated in vitro by PTEN and neutrophil gelatinase-associated lipocalin (NGAL) [161,162,163,164,165,166]. This evidence concerns the gene TSPAN8 and pancreatic adenocarcinoma.