In addition, FAK-KD mouse CAFs are oriented differently compared to FAK-WT mouse CAFs in relation to the tumor in vivo, are unable to deposit ‘tracks’ that tumor cells can follow during migration, are significantly less contractile in vitro, and, in the case of human FAK-KD CAFs, deposit fewer core ECM proteins, including collagens, glycoproteins, and proteoglycans. This evidence concerns the gene ART4 and neoplasm.