ACTA1 and neoplasm: Depletion of αSMA+ myofibroblasts in the KTC (Ptf1a-Cre/+;LSL-KrasG12D/+;Tgfbr2flox/flox) mouse model of PDAC [70,72] actually promotes EMT and tumorigenesis, and leads to poorer survival [70].This study challenged prior evidence suggesting that the αSMA+ myofibroblasts in the PDAC tumor stroma are pro-tumorigenic and are responsible for disease progression [73].