The general process of invadopodia initiation has been described in other tumor cell models and includes a biochemical stimulus that activates the potent oncogenic kinase Src, which then phosphorylates multiple downstream substates resulting in recruitment and assembly of the actin nucleation machinery complex (N-WASP, Arp2/3, Cofilin) (Figure 2A) [84]. Here, WASL is linked to neoplasm.