EVs derived from hypoxia pancreatic adenocarcinoma cells transported miR-301a-3p in a HIF1a- or HIF2a-dependent manner, induced macrophage M2 polarization through activation of the PTEN/PI3Kγ signaling pathway, and thus promoted lung metastasis of pancreatic adenocarcinoma cells [48]. Here, EPAS1 is linked to pancreatic adenocarcinoma.