AKT1 and malignant colon neoplasm: Another study also found that colon-cancer-cell-derived exosomal miR-934 induced macrophage M2 polarization through down regulation of PTEN expression and activation of PI3K/AKT signaling pathways, and M2-type macrophages secreted CXCL13 to affect the liver immune status, induce PMN formation, and promote liver metastasis of colon cancer [47].