ANGPTL2 and Familial prostate cancer: MiR-378a-3p from prostate-cancer-cell-derived EVs promoted osteolysis through activation of the Dyrk1a/Nfatc1/Angptl2 axis in bone marrow macrophages, which played an important role in prostate cancer bone metastasis and could be a potential predictor of metastatic prostate cancer [119].