The exosomal miR-638 derived from hepatocellular carcinoma (HCC) cell HuH-7M inhibited VE-calmodulin and ZO-1 expression, and further diminished the endothelial junctional integrity, thereby enhancing vascular permeability and initiating PMN, thus promoting tumor metastasis [60]. The gene discussed is TJP1; the disease is neoplasm.