For example, the GC-cell-derived exosomal miR-106a increased fibronectin deposition, and remodeled the ECM to establish proper PMN and promote GC peritoneal metastasis by targeting Smad7 and TIMP2 in peritoneal mesothelial cells to activate the TGF-β pathway [69]. The gene discussed is TGFB1; the disease is gastric cancer.