Cell cycle, histone pathway, PI3K/AKT/mTOR, and chromatin remodeling are the four major signaling pathways identified to be deregulated in bladder cancer according to TCGA-derived data, with cell-cycle-related gene alterations the most common, present in over 90% of bladder carcinoma cases [8]. The gene discussed is PIK3CA; the disease is urinary bladder carcinoma.