Several molecular and genetic mechanisms, such as HCC-associated long noncoding RNA (HANR), VEGF-C and -D, VEGF receptor (VEGFR)-3, heparanase-1, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), hypoxia-inducible factor (HIF)-2a and homeobox prospero-like protein-1 (Prox-1), showed correlations with peritumoral lymphangiogenesis in HCC and associations with a greater risk of metastasis [1,66,67,68,69,70,71]. Here, HPSE is linked to hepatocellular carcinoma.