VEGFC and neoplasm: They also reported that high tumor expression of VEGF-C, which promotes lymphangiogenesis and metastasis [41,87,88,89], was associated with poor prognosis in patients with CRLM (MST: approximately 1 year in VEGF-C-positive patients vs. 2 years in VEGF-C-negative patients, p = 0.010) [87].