In this paper, we reported the higher uptake of ESBP-BSANPs-FITC in ovarian cancer cells with low CD44 expression (A2780/CP70 and ID8) than that of BSANPs-FITC, and the lower IC50 of ESBP-BSANPs-PTX in these cell lines than that of free PTX. Here, CD44 is linked to ovarian carcinoma.