Our results show the prevalence of the germline BRCA2 pathogenic variant c.7561delA, p.(Ile2521SerfsTer3) among individuals recruited in the Rimini district, Italy, consistent with being a high-risk population for HBOC syndrome and for PDAC, for which we calculated the risk of occurrence. The gene discussed is BRCA2; the disease is Hereditary breast and ovarian cancer syndrome.