BRCA2 and cancer: Furthermore, our study provides evidence of an increased risk of both PDAC and BC in BRCA2 carriers, although there are limitations due to the small sample size, allowing us to hypothesize that a major prevalence of this germline BRCA2 PV on the Emilia Romagna eastern coast could be a population-specific genetic feature of positive carriers and could have helpful therapeutic implications for patients and cancer risk prevention in their relatives.