CHRNA3 and metastatic neoplasm: In contrast, in 14/30 samples of patients with metastatic disease, PHOX2B (n = 13, 9.2 copies/mL, range 0.4–47 copies/mL) and/or CHRNA3 (n = 4, mean 5.4 copies/mL, range 2.1–11 copies/mL) was detected.