TP53 and cancer: As these findings might be extended to p53 and p63 proteoforms, having relevance and an important impact on cancer prevention by predicting premalignant colorectal tumors, we aim here to focus on the analysis of the differential seroreactivity against the known proteoforms of p53 and p63, to determine the existence of cryptic epitopes absent in the canonical proteins, and whether the proteoforms could have higher diagnostic ability than the reference proteins.