TP53 and colorectal carcinoma: Although significant results were obtained only for Δ133p53γ (p-value = 0.008), due to the number of samples analyzed with the biosensing platform, the detection of autoantibodies against these four p53 and p63 isoforms using electrochemical biosensors showed a high diagnostic ability for CRC, with AUC, sensitivity, and specificity of 100% (Figure 7B).