In a multi-center prospective cohort, Mavaddat et al. did not find a breast cancer risk-reducing effect of RRSO in 2272 women with a BRCA1 GPV (HR: 1.23, 95% CI: 0.95–1.61) followed-up for a mean of 5.4 years [11]. The gene discussed is BRCA1; the disease is breast carcinoma.