RRSO did not decrease breast cancer risk overall (HR: 1.23, 95% CI: 0.85–1.78), or for BRCA1 (HR 1.29: 95% CI: 0.81–2.05) or BRCA2 GPV separately (HR: 1.13, 95% CI: 0.62–2.06). The gene discussed is BRCA2; the disease is breast carcinoma.