CD8A and neoplasm: After CD8+ T cells were treated with these exosomes, the levels of CD8+ T cell surface exhaustion markers, such as PD-1 and T cell immunoglobulin and mucin domain-containing protein 3, were significantly increased, and that of tumor suppressor factors, such as interferon-γ, interleukin-2, and tumor necrosis factor-α, were reduced.