Furthermore, silencing of this molecule could attenuate the highly metastatic attributes of HCC-derived exosomes on the malignant biological behavior of low metastatic HCC cells, related to the suppressed function of highly metastatic HCC-derived exosomes, resulting in the failure of Akt/GSK-3β/β-catenin signaling and JNK1/2 signaling [82]. The gene discussed is MAPK8; the disease is hepatocellular carcinoma.