Seven of the rare candidate predisposition variants found to segregate in prostate cancer cases who were members of high-risk prostate cancer pedigrees were in known BROCA genes, including the MUTYH variant already discussed, as well as variants in APC (ClinVar: conflicting interpretations of pathogenicity), BRCA1 (benign), MSH6 (uncertain significance), PTCH1 (conflicting), SDHC (not classified), and SLX4 (benign/likely benign). The gene discussed is SLX4; the disease is prostate cancer.