Lipopolysaccharide-responsive and beige-like anchor protein (LRBA), the single candidate predisposition variant identified in a cousin pair and also confirmed with significant association to prostate cancer in the UK Biobank case/control analysis, is involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (this function was assigned by similarity). Here, LRBA is linked to prostate cancer.