BAP1 and neoplasm: In a recent study [29], genomic analysis of more than 1000 pleural mesothelioma samples showed that the most frequent molecular alteration was a loss of function (LOH) of specific tumor suppressor genes such as CDKN2A, CDKN2B, BAP1 and NF2 (15.20% of the total cases each), which is in line with all previous studies.