Among these 12 proteins, several were overexpressed proteins, with links to OSCC or cancer such as interstitial collagenase (MMP1), stress-induced-phosphoprotein 1 (STIP1), glia-derived nexin (SERPINE2), membrane frizzled-related protein (MFRP) and MAP kinase-activated protein kinase 3 (MAPKAPK3). The gene discussed is MFRP; the disease is cancer.