As important representatives, tissue inhibitor of matrix metalloproteinases-2 (TIMP2), interstitial collagenase MMP-1, gelsolin, peroxiredoxin 1 and glia-derived nexin were significantly up-regulated, and various components of the complement cascade, cathepsin A and angiostatin were down-regulated in the tumor vs. healthy control group. The gene discussed is TIMP2; the disease is neoplasm.