EGFR and head and neck squamous cell carcinoma: For example, HPV+ tumors often display amplification of the genomic regions 20q11 (E2F1), 12p13 (LAG3, TNFRSF1) and 3q27/28 (ATR, BCL6, PSMD2, MAP3K13, ALG3, IGF2BP2), while HPV- HNSCC cells are enriched for amplifications of 7p11 (EGFR), 8p11 (FGFR1), 17q12 (ERBB2, CDK12), 5p15 (TERT), 9p24 (JAK2, CD274), 15q26 (ALDH1A3, IGF1R) and the coamplification of 11q13 (CCND1) and 11q22 (BIRC2, YAP1) [20,21,22,23,24].