A comprehensive analysis demonstrates that OC organoids maintained tumors’ histological characteristics and genomic landscape (nuclear and cellular atypia, and biomarker expression, such as p53 and PAX8), remained highly similar at the gene expression, even after extended passaging, recapitulated OC hallmarks, such as somatic single-nucleotide variants (S-SNVs), CNVs and captured tumor heterogeneity [35]. The gene discussed is TP53; the disease is neoplasm.