IGF1 and cancer: It has been revealed that omipalisib treatment could prevent the colony formation of cancer stem cells and induce autophagic cell death because clonogenicity depends on basic fibroblast growth factor (bFGF) and Insulin-like growth factor 1 (IGF-1) signaling via AKT and ERK pathways and omipalisib in combination with an ERK inhibitor, such as MEK162 can suppress colony formation [121].