Moreover, IL-6 protects tumor cells from the paclitaxel- and cisplatin-associated cytotoxic effects by downregulating caspase3 (Cas3) and upregulating antiapoptotic proteins, such as X-linked inhibitor of apoptosis (XIAP), B-cell lymphoma 2 (Bcl-2), and B-cell lymphoma-extra large (Bcl-xL) in resistant cancer cells. The gene discussed is XIAP; the disease is neoplasm.