Background: Alongside their BCR-ABL specificity, TKIs used in chronic myeloid leukemia also target other tyrosine kinases expressed in the kidney such as PDGFR, c-KIT, SRC, and VEGFR, which may result in specific renal adverse drug reaction (ADR). The gene discussed is PDGFRB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.