MYCN and neuroblastoma: Recurrent SCA in NB involve losses of chromosome 1p, 3p, 4p, 6q, 11q, and 19p, and gains of 1q, 2p, 7q, and 17q that together with amplification of MYCN oncogene, specific amplifications on 2p and 12q and loss of whole chromosome X, are all markers of high-risk disease [13,14,15,16,17,18,19,20].