MYCN and neuroblastoma: NB is mainly driven by structural chromosomal aberrations such as losses of chromosomes 1p, 3p, 4p, 6q, 11q, 19p, gains of 1q, 2p, 7q, 17q, amplifications of genes on 2p and 12q and of MYCN oncogene, and loss of whole chromosome X, which are all markers of high-risk disease [13,14,15,16,17,18,19,20].