Seminal studies have implicated the role of Semaphorins in cancer-induced neurogenesis and aggressivity [12,15,24], and in our previous study, we identified the TGFβ pathway as a mediator of cancer innervation, promoting the expression of the Semaphorin-4F in breast cancer cells and leading to increased cancer innervation associated with enhanced metastasis [19]. Here, SEMA4F is linked to cancer.