The NMuMG-E/M model of breast cancer plasticity provides a unique advantage for studying cancer-induced neuronal differentiation in direct coculture, as it avoids the use of cytokines such as TGFβ, EGF, FGF, or HGF to trigger EMT, which likely could directly impact neuronal cells if applied directly to the coculture [48,49]. This evidence concerns the gene TGFB1 and breast carcinoma.