Then, NB cells were treated with BI-D1870 in combination with 740 Y-P (an AKT agonist), and we found that the proportion of apoptosis after adding 740 Y-P was significantly lower than using BI-D1870 alone, and the cell cycle arrest was also significantly alleviated (Figure 7J). The gene discussed is CACNA1A; the disease is neuroblastoma.