- Tumor-induced genetically modified stromal and BM fibroblasts increase versican, tenascin, BDFN, CCL5, CXCL5, and CXCL16 - Frequency of normal breast CD34+ fibroblasts, markedly decreases, and that of αSMA+ fibroblasts increases- CAFs have higher levels of RhoA and Rac1 than NFs. The gene discussed is VCAN; the disease is neoplasm.