RN7SL1 hence becomes unshielded in stromal exosomes, and upon transfer to immune cells and BC cells, drives an inflammatory response and activates damage-associated molecular patterns (DAMPs) pattern recognition receptor (PRR) retinoic acid-inducible gene I (RIG-I) to enhance tumor growth, metastasis, and therapy resistance, respectively [241]. Here, RIGI is linked to breast cancer.