CAF heterogeneity can be categorized into the inflammatory CAF group with low αSMA expression and high IL-6 expression, the TGFβ-dependent myofibroblast CAFs with high αSMA expression, or tumor suppressive CAFs with inhibitory effects mediated through stroma-specific Hedgehog (Hh) activation [230]. This evidence concerns the gene TGFB1 and neoplasm.