Similarly, genes with unique, high expression in colon submucosal fibroblasts relative to other fibroblasts are downregulated in CRC, including the NK2 homeobox 3 (NKX2)-Wnt family member 2B (WNT2B), an effect that may be related to the development of colorectal CAFs [70,349]. The gene discussed is WNT2B; the disease is colorectal carcinoma.