Co-culture of exosomes containing miR-10b with fibroblasts significantly suppresses PIK3CA expression in fibroblasts and decreases PI3K/AKT/mTOR pathway activity, reduces their proliferation, and converts them to CAFS expressing TGFβ and αSMA, which are able to promote CRC growth in vitro and in vivo [280]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.