The other lineage is the IL-1-responsive inflammatory CAF population, located distal to tumor nests in a desmoplastic area, coding for increased Jak/STAT signaling pathway members, interleukins, chemokines, and cytokines such as Cxcl1, 2, or 3, IL-6, IL-11, IL-21 and Lif [39,68,369,370]. Here, LIF is linked to neoplasm.