Treatment of tumor-bearing mice with polyethylene glycol (PEG)ylated liposomes loaded with salvianolic acid-B (Dan Phenolic Acid A), a small molecule natural product used in traditional medicine as an antifibrotic, can interfere with CAFs by inhibiting the secretion of TGFβ1, reduce collagen deposition and increase the penetration of nanoparticles into tumors [538]. The gene discussed is TGFB1; the disease is neoplasm.