SPP1 and neoplasm: In direct co-incubation experiments or through incubation in tumor conditioned medium, bone marrow MSCs increase the secretion of osteopontin (OPN), IL-8, and FGF-2, increasing their ability to act as chemoattractants to cancer cells, while decreasing vimentin and αSMA expression, which in vivo would act to keep them in the microenvironment by decreasing their migration [175].