LGALS1 and neoplasm: These proteins are fructose bisphosphate aldolase A, plasminogen activator inhibitor 1, cathepsin L, membrane annexin A5, 14-3-3σ protein, cystatin C, complement component C1s precursor, Cu/Zn-superoxide dismutase (SOD), heterogeneous nuclear ribonucleoprotein A1, Rho-GDP dissociation inhibitor 1 and Galectin 1 [348], and play roles in tumor progression by protecting cells against ROS injury, in protein degradation, invasion and metastasis signaling [348].