HAVCR2 and neoplasm: This is reflected by Hepatitis A virus cellular receptor 2 (HAVCR2, TIM3), lymphocyte activating gene (LAG)3, and ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, CD39) marker expression, supporting a role for CAFs in directly suppressing tumor-specific T-cell function in an antigen-dependent fashion [485].