SPARC and familial pancreatic carcinoma: Patient survival analysis and immunohistochemistry of surgical samples identified cytidine deaminase (CDA), EGF-like repeats and discoidin domains (EDIL)3, ITGB4, plasminogen activator, urokinase receptor (PLAUR) and SPARC (osteonectin), cwcv- and kazal-like domains proteoglycan (SPOCK)1 as SHH-dependent stromal factors that are associated with poor prognosis in pancreatic cancer patients [470].