Fibroblasts that inhibit cancer cell growth in contact co-culture exhibit differences in the Rho signal pathway and in potential individual regulators such as IL-6, MAPK8, MAP2K4, PRKCA, JUN, signal transducer and activator of transcription (STAT)3, and STAT5A compared to non-inhibitory fibroblasts [111]. This evidence concerns the gene STAT3 and cancer.