Administration of ATRA to mice in a pancreatic cancer tumor model rendered pancreatic stellate cells quiescent, reversed the secretion of cytokines, chemokines, including CXCL12, which regulate T-cell migration towards the stellate cells and away from the tumor, and of adhesion molecules, and increased the numbers of CD8+ T-cells in juxtatumoral compartments [491,530]. The gene discussed is CXCL12; the disease is neoplasm.