These changes correspond to increased mRNA levels and expression patterns of core clock genes basic helix-loop-helix ARNT-like 1 (BMAL1), circadian locomotor output cycles kaput protein (CLOCK), cryptochrome circadian regulator 1-2 (CRY1-2), period circadian regulator 1-3 (PER1-3), and clock-controlled genes WEE1 G2 checkpoint kinase (WEE1) and cMYC in cancer cells placed in CAF co-culture or treated with exogenous TNFα, and resulted in increased resistance to chemotherapy [333]. The gene discussed is TNF; the disease is cancer.