CD8A and familial pancreatic carcinoma: Pancreatic stellate cells in the juxtatumoral compartment also modulate resistance to cellular immunity in pancreatic cancer through the exclusion of FoxP3+, CD56+, CD20+ or CD8+ T-cells through their characteristic desmoplastic reaction, and by attracting CD8+ T-cells away from tumor cells through secretion of CXCL12 [491].