UPF1 and cancer: miR-210 is taken up by lung cancer cells, inhibits UPF1 RNA helicase and ATPase (UPF1) involved in mRNA nuclear export and surveillance and phosphatase and tensin homolog (PTEN), but activates the PTEN/PI3K/AKT pathway and broadly enhances cancer cell migration, proliferation, invasion and EMT status [275].