1,25 dihydroxy-vitamin D3 downregulates NRG1, WNT5A, PDGFC, genes associated with proliferation, and increases the expression of NFKBIA, TREM-1, genes involved in immune modulation, effects consistent with the anti-tumor effects of 1,25 dihydroxy-vitamin D3 in BC [513]. The gene discussed is WNT5A; the disease is neoplasm.