IGFBP5 and keloid: Growing fibroblasts cultured from keloids demonstrate glucocorticoid resistance, decreased expression of the Wnt inhibitor SFRP1, SFRP2, MMP-3 and dermatopontin (DPT), and increased expression of insulin-like growth factor binding protein 5 (IGFBP5) and jagged 1 (JAG1), likely controlled by altered epigenetic programming with an altered pattern of DNA methylation and histone acetylation [399].