Lung cancer cells transform NFs into CAFs by causing an increase in CAF miR-31 and a decrease in their miR-1 and miR-206 content, effects which induce the expression of VEGFA/CCL2 and FOXO3a and promote tumor angiogenesis, accumulation of tumor-associated macrophages, tumor growth, and lung metastasis [143]. Here, FOXO3 is linked to neoplasm.