Once again, this is circumstance-specific, and phenotypically opposite data in nasopharyngeal carcinomas, where αSMA+ SDF1+ CXCR4+ CAFs are associated with increased CD133+/VEGFR2+ cells and increased microvessel density in the stroma surrounding cancer nests suggest induction of neoangiogenesis by CAFs [497]. The gene discussed is CXCL12; the disease is cancer.