CHI3L1 and prostate neoplasm: Prostate tumors from AA patients have increased reactive stroma associated with chronic inflammatory infiltrates compared to those from Caucasian patients, with AA CAFs having a greater expression of proinflammatory paracrine mediators, including brain-derived neurotrophic factor (BDNF), chitinase 3-like 1 (CHI3L1), dipeptidyl peptidase 4 (DPPIV), FGF-7, IL-18 binding protein (BP), IL-6, and VEGF than Caucasian CAFs [403].