AKT1 and breast cancer: Examples of exosomal proteins common to both cells include members of the annexin family of calcium-dependent phospholipid-binding proteins, involved in the regulation of cellular growth and in signal transduction pathways, histone H4 protein, involved in epigenomic cell alterations associated with increased malignant properties, and the AKT pathway modulator calmodulin, associated with a poor prognosis in BC patients.