CXCL8 and colorectal carcinoma: MSCs co-cultured with colorectal cancer (CRC) cells upregulate many factors, of which IL-8 is the most highly upregulated angiogenesis factor, through which they induce human umbilical vein endothelial cell (HUVEC) proliferation and migration, tube-formation, and CRC cell proliferation in vitro and angiogenesis in vivo [166].