Non-contact co-incubation of normal human foreskin fibroblasts of the cell line Hs68 (HsFb) with human lung carcinoma A549 cells suppresses cancer cell migration and metastasis mediated by TGFβ1-induced EMT, reduces E-cadherin, and elevates N-cadherin, SNAIL, vimentin, and MMP-9 via release of 5-methoxytryptophan (5-MTP) [100]. Here, CDH2 is linked to cancer.