Triple-negative BC-derived CAFs induce CXCL12-CXCR4-mediated recruitment and reprogramming of blood monocytes towards immune suppressive stabilin (STAB)1+ translocation associated membrane protein (TREM)2 high lipid-associated macrophages, which inhibit T-cell activation and proliferation and support an immunosuppressive microenvironment [450]. The gene discussed is CXCR4; the disease is breast cancer.