Comparison and analysis of gene expression profiles of early passage primary CAFs isolated from BC patient samples representing three main subtypes, ER+, triple-negative, and Her2+ yielded significant expression differences between CAFs derived from Her2+ and CAFs derived from triple-negative and ER+ BCs, particularly in pathways associated with cytoskeleton and integrin signaling involved in motility [360]. Here, ESR1 is linked to breast cancer.