CAF exosomes also contain high levels of Opa-interacting protein 5 antisense RNA (OIP5-AS)1, which significantly downregulates miR-142-5p [273] and miR-34a [274] by acting as a sponge, thereby upregulating PD-L1, suppressing PBMS killing activity and promoting tumor progression. The gene discussed is CD274; the disease is neoplasm.