Cancer cells enhance the tumorigenic potential of fibroblasts by secreting pro-inflammatory cytokines, such as LIF and IL-6 to mediate the epigenetic modification of CAFs, which, in turn, secrete LIF and IL-6 and form a feedback loop to enhance actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration [230]. This evidence concerns the gene LIF and cancer.