External forces can upregulate transcription factors β-catenin, Hif1α, Twist, Snail, Smad2/3, STAT3, AP-1, c-Myb, Lef1, MRTFA, p53, p300ZNF217 and Yorkie-homologues YAP and/or TAZ, downregulate SRY-related HMG-box (SOX)2 and Nanog, and variably regulate NFκb by tumor type [424], leading to cancer progression. The gene discussed is TP53; the disease is cancer.