TSG-6 secreted by CRC cells activates Janus kinase (JAK)2-STAT3 and NF reprogramming into cancer-associated fibroblasts with upregulation of pro-metastatic cytokines CCL5 and MMP-3, higher motility in vitro, and increased support of cancer metastasis in vivo by TSG-6–expressing fibroblasts [231]. Here, MMP3 is linked to cancer.