For this purpose, we analyzed the levels of IL-1β, IL-6, IL-8, IL-10, TNF-α and IL-12p70 in a group of 70 patients with ESCC and 70 healthy individuals and detected increased levels of IL-1β, IL-6, IL-8 and IL-10 in patients with ESCC compared to controls. This evidence concerns the gene IL10 and esophageal squamous cell carcinoma.