S100A4 and cancer: Global hypomethylation also contributes to genomic instability and the rupture of DNA, which is often accompanied by loss of the imprint of some oncogenes, such as urokinase protease, mesothelin, claudin, heparinase, E-cadherin, proopiomelanocortin (POMC), and S100A4 (S100 calcium-binding protein A4), which leads to the development of cancer.