CDH1 and neoplasm: DNA methylation is influenced by factors such as cell–cell and cell–extracellular matrix interactions in the context of tissues, and this leads to alterations in the methylation profiles silencing or overexpressing genes such as E-cadherin, which play a very important role in the processes of disseminating and acquiring a migratory phenotype that is dependent on the epithelial–mesenchymal transition (EMT) of tumor cells, the existing evidence showing relationships among the variations.