IGF1 and Miyoshi myopathy: During the transition from the avascular to the vascular phase, the activation of oncogenes such as c-myc, c-fos, c-jun, and Jun-B induces MM cells to secrete high amounts of pro-angiogenic cytokines, including vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), hepatocyte growth factor (HGF), angiopoietin-1, and insulin-like growth factor 1 (IGF-1) [13,14,15].