These unfavorable results could be related to the complexity of tumor angiogenesis, which involves not only the VEGF axis but also alternative cytokines and intracellular pathways [44,45] as well as miRNAs [35,36] and extracellular vesicles [37], highlighting that anti-angiogenic treatment should entail the simultaneous targeting of multiple intracellular pathways. This evidence concerns the gene VEGFA and neoplasm.