FLT3 and acute myeloid leukemia: The AML cell lines MOLM-14, MV4-11, Kasumi, and THP-1 were chosen for assessment in our model as they represent some of the most common genetic and cytogenetic abnormalities observed in AML patients, including those poor prognostic subtypes carrying FLT3 internal tandem duplication [28] and MLL-gene fusions [29], as well as for representing different possible differentiation status of AML blasts.