This is related to the fact that activated NK cells secrete mainly IFNγ and GM-CSF, while CAR-T cells secrete several pro-inflammatory cytokines, such as IL-1, IL-2, IL-6, TNFα, IL-8, IL-10, and IL-15, which are more prone to trigger CRS [343,344]. This evidence concerns the gene TNF and congenital rubella syndrome.