IFNG and neoplasm: According to cytokine stimulation in the TME, resident macrophages may polarize to the M1-like antitumor and pro-inflammatory subtype (through IFNγ and TNFα or recognition of LPS) that activates the adaptive immune system [383,384,385,386] or to the M2-like protumoral and immunoregulatory subtype (through IL-4, IL-10, IL-13, and TGF-β), which promote angiogenesis and tissue repair and are strongly associated with tumor survival and progression [387,388,389,390].