Regarding radiolabelled choline, in 24 patients with locally advanced HCC and initially increased AFP levels, Hartenbach et al. employed PET/CT with 18F fluoroethylcholine to predict response to SIRT: in these cases, reduction in SUV max and in tumour-to-background ratio after Y-90 administration showed the highest predictive value [57]. This evidence concerns the gene AFP and hepatocellular carcinoma.