This study revealed that hexokinase activity was significantly higher in high-grade HCC than in low-grade HCC, the glucose-6-phosphatase activity of high-grade HCC tended to be lower than in low-grade type HCCs, and FDG uptake measured by the standard uptake value (SUV) was significantly higher in high-grade HCC than in low-grade HCC [24]. Here, G6PC1 is linked to hepatocellular carcinoma.