Therefore, in this study, we conducted a retrospective multi-centric analysis to help determine the potential role of CT-based radiomics and delta-radiomics in predicting tumoral response and survival in patients with advanced NSCLC treated with PD-1/PD-L1 inhibitors, exploring the added value of multi-lesion analysis and clinical combined analyses. The gene discussed is CD274; the disease is non-small cell lung carcinoma.