In the last decade, immune checkpoint inhibitors (ICIs) targeting programmed death-1 (PD-1) or programmed death ligand-1 (PD-L1) have demonstrated unprecedented efficacy in increasing clinical response and survival of patients with treatment-naïve or previously treated advanced non-small cell lung cancer (NSCLC) [1,2,3,4]. Here, CD274 is linked to non-small cell lung carcinoma.