Indeed, GO analyses revealed that the main regulators of MHC class I and II were highly expressed in CRC patients presenting HDAC2 deregulations, suggesting that this regulator plays a fundamental role in the programming and differentiation of these immune complexes through mechanisms that might be explained by HDAC2-mediated posttranscriptional deacetylase activities. This evidence concerns the gene HDAC2 and colorectal carcinoma.